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Kunkle BW, Grenier-Boley B, Sims R, et al. Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity For Further Reading 225 and lipid processing. Nat Genet. 2019;51(3):414–430. doi: 10.1038/s41588-019-0358-2. Epub 2019 Feb 28. Erratum in: Nat Genet. 2019 Sep;51(9):1423–1424.

Levine DA, Gross AL, Briceño EM, et al. Association between blood pressure and later-life cognition among black and white individuals. JAMA Neurol. 2020;77(7):810–819. doi: 10.1001/jamaneurol.2020.0568

Li H, Wang B, Wang Z, et al. Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP. Proc Natl Acad Sci. 2010;107(40):17362–17367. doi: 10.1073/pnas.1012568107

Lim YY, Hassenstab J, Goate A, et al. Effect of BDNFVal66Met on disease markers in dominantly inherited Alzheimer’s disease. Ann Neurol. 2018;84(3):424–435. doi: 10.1002/ana.25299. Epub 2018 Aug 25.

Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G. Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nat Rev Neurol. 2013;9(2):106–118. doi: 10.1038/nrneurol.2012.263. Epub 2013 Jan 8. Erratum in: Nat Rev Neurol. 2013. doi: 10.1038/nmeurol.2013.32. Liu, Chia-Chan [corrected to Liu, Chia-Chen].

Lourida I, Hannon E, Littlejohns TJ, et al. Association of lifestyle and genetic risk with incidence of dementia. J Am Med Assoc. 2019;322(5):430–437. doi: 10.1001 /jama.2019.9879

Macey PM, Prasad JP, Ogren JA, et al. Sex-specific hippocampus volume changes in obstructive sleep apnea. Neuroimage Clin. 2018;20:305–317. doi: 10.1016 / j.nicl.2018.07.027

Mata IF, Leverenz JB, Weintraub D, et al. APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease. JAMA Neurol. 2014;71(11):1405–1412. doi: 10.1001/jamaneurol.2014.1455

Miller BL. Science denial and COVID conspiracy theories: potential neurological mechanisms and possible responses. J Am Med Assoc. 2020;324(22):2255–2256. doi: 10.1001/jama.2020.21332

Miller T, Cudkowicz M, Shaw PJ, et al. Phase 1–2 trial of antisense oligonucleotide tofersen for SOD1 ALS. N Engl J Med. 2020;383(2):109–119. doi: 10.1056/NEJM oa2003715

Molloy AM, Pangilinan F, Mills JL, et al. A common polymorphism in HIBCH influences methylmalonic acid concentrations in blood independently of cobalamin. Am J Hum Genet. 2016;98(5):869–882. doi: 10.1016/j.ajhg.2016.03.005. Epub 2016 Apr 28. 226 For Further Reading

Montagne A, Nation DA, Sagare AP, et al. APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. Nature. 2020;581(7806):71–76. doi: 10.1038/s41586-020-2247-3. Epub 2020 Apr 29.

Mormino EC, Betensky RA, Hedden T, et al. Amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease. Neurology. 2014;82(20):1760–1767. doi: 10.1212/WNL.0000000000000431. Epub 2014 Apr 18.

Nordström A, Nordström P. Traumatic brain injury and the risk of dementia diagnosis: a nationwide cohort study. PLoS Med. 2018;15(1):e1002496. doi: 10.1371/journal.pmed.1002496

O’Hara R, Luzon A, Hubbard J, Zeitzer JM. Sleep apnea, apolipoprotein epsilon 4 allele, and TBI: mechanism for cognitive dysfunction and development of dementia. J Rehabil Res Dev. 2009;46(6):837–850. doi: 10.1682/jrrd.2008.10.0140

Oveisgharan S, Wilson RS, Yu L, Schneider JA, Bennett DA. Association of earlylife cognitive enrichment with Alzheimer disease pathological changes and cognitive decline. JAMA Neurol. 2020;77(10):1217–1224. doi: 10.1001 /jamaneurol.2020.1941

Poewe W, Seppi K, Tanner CM, et al. Parkinson disease. Nat Rev Dis Primers. 2017;3:17013. doi: 10.1038/nrdp.2017.13

Proskovec AL, Rezich MT, O’Neill J, et al. Association of epigenetic metrics of biological age with cortical thickness. JAMA Netw Open. 2020;3(9):e2015428. doi: 10.1001/jamanetworkopen.2020.15428

Rainville JR, Hodes GE. Inflaming sex differences in mood disorders. Neuropsychopharmacology. 2019;44(1):184–199. doi: 10.1038/s41386-018-0124-7. Epub 2018 Jun 19.

Raz L, Knoefel J, Bhaskar K. The neuropathology and cerebrovascular mechanisms of dementia. J Cereb Blood Flow Metab. 2016;36(1):172–186. doi: 10.1038/jcbfm.2015.164

Reckelhoff JF. Gender differences in the regulation of blood pressure. Hypertension. 2001;37(5):1199–1208. doi: 10.1161/01.hyp.37.5.1199

Reiman EM, Chen K, Alexander GE, et al. Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer’s dementia. Proc Natl Acad Sci USA. 2004;101(1):284–289. doi: 10.1073/pnas.2635903100. Epub 2003 Dec 19.

Rosenberg RN, Lambracht-Washington D, Yu G, Xia W. Genomics of Alzheimer disease: a review. JAMA Neurol. 2016;73(7):867–874. doi: 10.1001/ jamaneurol.2016.0301

Rossor MN, Fox NC, Mummery CJ, Schott JM, Warren JD. The diagnosis of young-onset dementia. Lancet Neurol. 2010;9(8):793–806. doi: 10.1016/S1474-4422(10)70159–9