Почему тело дает сбой. Как ежедневные привычки могут незаметно нас убивать

В кишечнике Оливии они стали особенно непокорными: Yi Rang Na et al., “Macrophages in Intestinal Inflammation and Resolution: A Potential Therapeutic Target in IBD”, Nature Reviews Gastroenterology & Hepatology 16, no. 9 (Sept. 1, 2019).

«Какая разница, – говорил он: Markel, The Kelloggs.

также является важным триггером воспаления кишечника: Alessandra Geremia et al., “Innate and Adaptive Immunity in Inflammatory Bowel Disease”, Autoimmunity Reviews 13, no. 1 (Jan. 2014).

«неудивительно, что человеческая желудочная машина сломалась»: John Harvey Kellogg, The New Dietetics: What to Eat and How: A Guide to Scientific Feeding in Health and Disease (Battle Creek, MI: Modern Medicine Publishing, 1923).

что может нанести вред организму: Karen Windey, Vicky De Preter, and Kristin Verbeke, “Relevance of Protein Fermentation to Gut Health”, Molecular Nutrition & Food Research 56, no. 1 (Jan. 2012); Stephen J. D. O’Keefe et al., “Fat, Fibre and Cancer Risk in African Americans and Rural Africans”, Nature Communications 6 (2015); Devkota and Chang, “Nutrition, Microbiomes, and Intestinal Inflammation”.

всевозможные исследования на людях показали: Patricia Lopez-Legarrea et al., “The Protein Type within a Hypocaloric Diet Affects Obesity-Related Inflammation: The Resmena Project”, Nutrition 30, no. 4 (April 2014); Monique van Nielen et al., “Dietary Protein Intake and Incidence of Type 2 Diabetes in Europe: The Epic-Interact CaseCohort Study”, Diabetes Care 37, no. 7 (July 2014); Nathalie Bergeron et al., “Effects of Red Meat, White Meat, and Nonmeat Protein Sources on Atherogenic Lipoprotein Measures in the Context of Low Compared with High Saturated Fat Intake: A Randomized Controlled Trial”, The American Journal of Clinical Nutrition 110, no. 1 (2019); Heli E. K. Virtanen et al., “Dietary Proteins and Protein Sources and Risk of Death: The Kuopio Ischaemic Heart Disease Risk Factor Study”, American Journal of Clinical Nutrition 109, no. 5 (2019).

в том числе сероводород: Jose C. Clemente, Julia Manasson, and Jose U. Scher, “The Role of the Gut Microbiome in Systemic Inflammatory Disease”, British Medical Journal 360 (2018); Song and Chan, “Environmental Factors, Gut Microbiota”; E. Magee, “A Nutritional Component to Inflammatory Bowel Disease: The Contribution of Meat to Fecal Sulfide Excretion”, Nutrition 15, no. 3 (March 1999); S. L. Jowett et al., “Influence of Dietary Factors on the Clinical Course of Ulcerative Colitis: A Prospective Cohort Study”, Gut 53, no. 10 (Oct. 2004).

раз за разом обнаруживают доказательства: Dong and Gupta, “Influence of Early Life”. A sugar in red meat: Maria Hedlund et al., “Evidence for a Human-Specific Mechanism for Diet and Antibody-Mediated Inflammation in Carcinoma Progression”, Proceedings of the National Academy of Sciences of the USA 105, no. 48 (Dec. 2, 2008).

Или гемовое железо: Lu Qi et al., “Heme Iron from Diet as a Risk Factor for Coronary Heart Disease in Women with Type 2 Diabetes”, Diabetes Care 30, no. 1 (2007).

и обнаружили их огромное количество в продуктах животного происхождения: Clett Erridge, “The Capacity of Foodstuffs to Induce Innate Immune Activation of Human Monocytes in Vitro Is Dependent on Food Content of Stimulants of Toll-Like Receptors 2 and 4”, British Journal of Nutrition 105, no. 1 (2011).

так много эндотоксинов, что их хватит, чтобы воспалить весь организм: Robert A. Vogel, Mary C. Corretti, and Gary D. Plotnick, “Effect of a Single High-Fat Meal on Endothelial Function in Healthy Subjects”, American Journal of Cardiology 79, no. 3 (Feb. 1, 1997).

где начал свою медицинскую практику: Stephen O’Keefe, email to author, May 2021.

который сделал похожие наблюдения: Brian Kellock, Fiber Man: The Life Story of Dr. Denis Burkit (Tring: Lion Publishing, 1985).

набрал двадцать афроамериканцев: O’Keefe et al., “Fat, Fibre and Cancer Risk”.

в том числе сравнение детей из Буркина-Фасо с детьми из Италии: Carlotta De Filippo et al., “Impact of Diet in Shaping Gut Microbiota Revealed by a Comparative Study in Children from Europe and Rural Africa”, Proceedings of the National Academy of Sciences of the USA 107, no. 33 (2010); H. L. Simpson and B. J. Campbell, “Review Article: Dietary FibreMicrobiota Interactions”, Alimentary Pharmacology and Therapeutics 42 (2015).

благотворение влияние на врожденную и адаптивную ветви иммунной системы: Melanie Schirmer et al., “Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity”, Cell 167, no. 4 (2016); Lisa Rizzetto et al., “Connecting the Immune System, Systemic Chronic Inflammation and the Gut Microbiome: The Role of Sex”, Journal of Autoimmunity 92 (Aug. 2018).