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Глава 4. Хореография генов

1 Изображение lac-репрессора, прикрепленного к ДНК, основано на структуре белков 1EFA и 1TLF из Protein Data Bank и на комбинированной иллюстрации Дэвида Гудселла: https://www.rcsb.org/structure

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2 Schleif R. DNA Looping. Annual Review of Biochemistry. 1992; 61: 199–223.

3 Vörös Z. et al. Proteins mediating DNA loops effectively block transcription. Protein Sci. 2017; 26: 1427–1438; Becker N. A. et al. Mechanism of promoter repression by lac repressor-DNA loops. Nucleic Acids Res. 2013; 41: 156–166.

4 История изучения генетической регуляции описана в Morange M. A History of Molecular Biology. Cambridge, MA: Harvard University Press, 2000.

5 Lambert S. A., et al. The human transcription factors. Cell. 2018; 172: 650–665.

6 Schoenfelder S., Fraser P. Long-range enhancer – promoter contacts in gene expression control. Nature Reviews Genetics. 2019; 20: 437–455.

7 Cronin C. A. et al. The lac operator-repressor system is functional in the mouse.

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8 О памяти, часах и других генетических схемах: Nelson P. C. Physical Models of Living Systems. W. H. Freeman, 2015; Alon U. An Introduction to Systems Biology: Design Principles of Biological Circuits. Boca Raton, FL: CRC Press, 2007. О циркадном ритме и его клеточных часах: Brown S. A. et al. (Re)inventing the circadian feedback loop. Dev. Cell. 2012; 22: 477–487; Maywood E. S. et al. Analysis of core circadian feedback loop in suprachiasmatic nucleus of mCry1-luc transgenic reporter mouse. Proc. Natl. Acad. Sci. 2013; 110: 9547–9552; Pett J. P. et al. Feedback loops of the mammalian circadian clock constitute repressilator. PLOS Comput. Biol. 2016; 12: e1005266.

9 Elowitz M. B., Leibler S. A synthetic oscillatory network of transcriptional regulators. Nature. 2000; 403: 335–338.

10 Stricker J. et al. A fast, robust and tunable synthetic gene oscillator. Nature. 2008; 456: 516–519.

11 Lawrence M. et al. Lateral thinking: How histone modifications regulate gene expression.

Trends in Genetics. 2016; 32: 42–56; Ho L., Crabtree G. R. Chromatin remodelling during development. Nature. 2010; 463: 474–484.

12 Allis C. D., Jenuwein T. The molecular hallmarks of epigenetic control. Nature Reviews Genetics. 2016; 17: 487–500; Boškoviс A., Rando O. J. Transgenerational epigenetic inheritance. Annual Review of Genetics. 2018; 52: 21–41; Heijmans B. T. et al. Persistent epigenetic differences associated with prenatal exposure to famine in humans. PNAS. 2008; 105: 17046–17049.

13 Painter R. C. et al. Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life. BJOG: An International Journal of Obstetrics & Gynaecology. 2008; 115: 1243–1249; Veenendaal M. V. E. et al. Transgenerational effects of prenatal exposure to the 1944–45 Dutch famine. BJOG: An International Journal of Obstetrics & Gynaecology. 2013; 120: 548–554.

Глава 5. Мембраны: жидкая кожа