Простое начало. Как четыре закона физики формируют живой мир

19 Palermo G. et al. The invisible dance of CRISPR-Cas9. Physics Today. 2019; 72: 30–36; CRISPR: Gene editing and beyond. Nature Video. 2017 (https://youtu.be/4YKFw2KZA5o); Jiang F., Doudna J. A. CRISPR – Cas9 structures and mechanisms. Annual Review of Biophysics. 2017; 46: 505–529. Эту статью сопровождает информативная компьютерная анимация структурных изменений Cas9, доступная на платформе YouTube: https://www.youtube.com/watch?v=XAtZEIyzd7g, https:

//www.youtube.com/watch?v=YaXoom7YAY.

20 О ранней истории CRISPR: Campbell M. Francis Mojica: The modest microbiologist who discovered and named CRISPR. Genomics Research from Technology Networks. 2019; October 14 (https://www.technologynetworks.com/genomics/articles/francis-mojica-the-modest-microbiologist-who-discovered-and-named-crispr-325093); Ishino Y. et al. History of CRISPR-Cas from encounter with a mysterious repeated sequence to genome editing technology. Journal of Bacteriology. 2018; 200: e00580-17; Lander E. S. The heroes of CRISPR. Cell. 2016; 164: 18–28. Последняя статья вызывает немало споров – см., например: Vence T. «Heroes of CRISPR» disputed.

Scientist Magazine. 2016; January 19 (https://www.the-scientist.com/news-opinion/heroes-of-crispr-disputed-34188) и Morange M. Why Eric Lander's controversial paper «The Heroes of CRISPR» is not solid historical research. American Scientist. 2016; February 17 (https://www.americanscientist.org/blog/macroscope/why-eric-lander%E2 %80 %99s-controversial-paper-%E2 %80 %9Cthe – heroes-of-crispr%E2 %80 %9D-is-not-solid-historical).

21 Jinek M. et al. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science. 2012; 337: 816–821.

22 Zimmer C. CRISPR natural history in bacteria

. Quanta Magazine. 2015; February 6 (https://www.quantamagazine.org/crispr-natural-history-in-bacteria-20150206/).

23 Gasiunas G. et al. Cas9 – crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria. PNAS. 2012; 109: E2579 – E2586.

24 Begley S. Who gets credit for CRISPR? Prestigious award singles out three. STAT. 2018; May 31 (https://www.statnews.com/2018/05/31/crispr-scientists-kavli-prize-nanoscience/); Bichell R. Science rewards eureka moments, except when it doesn't. NPR.org. 2016; November 2 (https:

//www.npr.org/sections/health-shots/2016/11/02/500331130/science-rewards-eureka-moments-except-when-it-doesn't); Guglielmi G. Million-dollar Kavli Prize recognizes scientist scooped on CRISPR. Nature. 2018; 558: 17–18.

25 Cong L. et al. Multiplex genome engineering using CRISPR/Cas systems. Science. 2013; 339: 819–823; Mali P. et al. RNA-guided human genome engineering via Cas9. Science. 2013; 339: 823–826.

26 Anzalone V. et al. Search-and-replace genome editing without double-strand breaks or donor DNA. Nature. 2019; 576: 149–157; Ledford H. Super-precise new CRISPR tool could tackle a plethora of genetic diseases. Nature. 2019; 574: 464–465.

27 Zsögön A. et al. De novo domestication of wild tomato using genome editing. Nature Biotechnology. 2018; 36: 1211–1216.

28 Tebas P. et al. Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. New England Journal of Medicine. 2014; 370: 901–910.