Грязные гены. «Большая стирка» для вашей ДНК. Как изменить свою наследственность

28. Folic acid is unnatural and not useful until processed into a useful form: Bailey, Stephen W., Ayling, June E. “The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake,” Proceedings of the National Academy of Sciences of the United States of America, 22 July 2009, http://www.pnas.org/content/106/36/15424.long.

29. Folic acid actually blocks methylation: Christensen, KE et al. “High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice,” The American Jounral of Clinical Nutrition, March 2015, https://www.ncbi.nlm.nih.gov/pubmed/25733650.

30. Take folate instead of folic acid: Lynch, Ben. “Folic Acid and Pregnancy | Is Folic Acid the Right Choice?” You Tube, 7 September 2016, https://www.youtube.com/watch?v=tnVRv0zGsFY&t=603s.

31. In 1998, FDA required “enrichment” of foods: “Folate,” National Institutes of Health, Accessed April 2017, https://ods.od.nih.gov/factsheets/Folate-HealthProfessional/.

32. The wrong amount of exercise: Reynold, Gretchen. “How Exercise Changes Our DNA,” Well, 17 December 2014, https://well.blogs.nytimes.com/2014/12/17/how-exercise-changes-our-dna/?_r=1.

33. Poor Sleep: Kirkpatrick, Bailey. “The Epigenetics of Sleep: 3 Reasons to Catch More Zzz’s,” What is Epigenetics, 3 March 2015, http://www.whatisepigenetics.com/the-epigenetics-of-sleep-3-reasons-to-catch-more-zzzs/.

34. Methyl groups used faster under stress: Bing, Yuntao et al. “Glucocorticoid-induced S-Adenosylmethionine Enhances the Interferon Signaling Pathway by Restoring STAT1 Protein Methylation in Hepatitis B Virus-infected Cells,” The Journal of Biological Chemistry, 30 September 2014, http://www.jbc.org/content/289/47/32639.full.

3. Каков ваш генетический профиль?

35. COMT affects estrogen metabolism: Cussenot, Olivier. “Combination of Polymorphisms From Genes Related to Estrogen Metabolism and Risk of Prostate Cancers: The Hidden Face of Estrogens,” Journal of Clinical Oncology, August 2007, http://ascopubs.org/doi/full/10.1200/JCO.2007.11.0908.

4. Анкета № 1: каким генам необходима «чистка»?

5. MTHFR, или мастер метилирования

36. MTHFR SNP’s can lead to a decreased risk of colon cancer: Xie, SZ. et al. “Association between the MTHFR C677T polymorphism and risk of cancer: evidence from 446 case-control studies,” Tumour Biology, 17 June 2015, https://www.ncbi.nlm.nih.gov/pubmed/26081619.

37. If MTHFR is born dirty, it can have up to one hundred SNPS or even more: “MTHFR[all],” National Center for Biotechnology Information, U.S. National Library of Medicine, Accessed April 2017, https://www.ncbi.nlm.nih.gov/clinvar/?term=MTHFR[all].

38. Supports of healthy methylation: Wilcken, W. et al. “Geographical and ethnic variation of the 677C>T allele of 5,10 methylenetetrahydrofolate reductase (MTHFR): findings from over 7000 newborns from 16 areas world wide,” Journal of Medical Genetics, 2003, http://jmg.bmj.com/content/40/8/619.

39. Health Conditions Related to SNPs in Your MTHFR: “Genopedia: MTHFR,” Center for Disease Control and Prevention, Accessed April 2017, https://phgkb.cdc.gov/HuGENavigator/huGEPedia.do?firstQuery=MTHFR&geneID=4524&typeSubmit=GO✓=y&typeOption=gene&which=2&pubOrderType=pubD

.

40. Cobalamin/B12 found in food: “Vitamin B₁₂,” Oregon State University Linus Pauling Institute Micronutrient Information Center, Accessed April 2017, http://lpi.oregonstate.edu/mic/vitamins/vitamin-B12#food-sources.

6. COMT. Внимательность и жизнерадостность, или спокойствие и отрешенность COMT

41. Catechols found in quercetin: “COMT Gene,” Genetic Home Reference, 11 April, 2017, https://ghr.nlm.nih.gov/gene/COMT#resources.