Загадка нестареющей медузы. Секреты природы и достижения науки, которые помогут приблизиться к вечной жизни

The Nobel Prize in Physiology or Medicine 2016, NobelPrize.org, Nobel Media AB 2020.

Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. Elegans, Kumsta C., Chang J., Schmalz J., Hansen M., Nature Communications (2017) 8(1): 1–12.

Walking the Oxidative Stress Tightrope: A Perspective from the Naked Mole-Rat, the Longest-Living Rodent, А. Rodriguez K. et al., Current Pharmaceutical Design (2011) 17(22): 2290–2307.

A wide diversity of bacteria from the human gut produces and degrades biogenic amines, Pugin B. et al., Microbial Ecology in Health and Disease (2017) 28(1): 1353881.

Cardioprotection and lifespan extension by the natural polyamine spermidine, Eisenberg T. et al., Nature Medicine (2016) 22(12): 1428–1438.

Higher spermidine intake is linked to lower mortality: A prospective population-based study, Kiechl S. et al., American Journal of Clinical Nutrition (2018) 108(2): 371–380.

Decrease in Polyamines with Aging and Their Ingestion from Food and Drink, Nishimura K., Shiina R., Kashiwagi K., Igarashi K., The Journal of Biochemistry (2006) 139(1): 81–90.

Зомби-клетки и как от них спастись

The Nobel Prize in Physiology or Medicine 2016, NobelPrize.org, Nobel Media AB 2020.

Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors, Takahashi K., Yamanaka S., Cell (2006) 126(4): 663–676.

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming, Ocampo A. et al., Cell (2016) 167(7): 1719–1733.e12.

Transplantation of mesenchymal stem cells from young donors delays aging in mice, Shen J., Tsai Y., Dimarco N., Long M., Sun X., Tang L., Scientific Reports (2011) 1.

Photoaged Skin Therapy with Adipose-Derived Stem Cells, Charles-de-Sá L. et al., Plastic & Reconstructive Surgery (2020) 145(6): 1037e–1049e.

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in MiceXu M. et al., The journals of gerontology. Series A, Biological sciences and medical sciences (2017) 72(6): 780–785.

Naturally occurring p16 Ink4a-positive cells shorten healthy lifespan, Baker D. et al., Nature (2016) 530(7589): 184–189.

Senolytics improve physical function and increase lifespan in old age, Xu M., Pirtskhalava T., Farr J. N., Nat Med 24, 1246–1256 (2018).

Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor, Coppé J., Patil C., Rodier F., Sun Y., Muñoz D., Goldstein J., Nelson P., Desprez P., Campisi J., PLoS biology (2008) 6(12).

Programmed cell senescence during mammalian embryonic development, Muñoz-Espín D. et al., Cell (2013) 155(5): 1104.

An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA, Demaria M. et al., Developmental Cell (2014) 31(6): 722–733.

Apoptosis, Growth, and Aging, Cole L., Kramer P., Elsevier (2016), 63–66.

Senolytics improve physical function and increase lifespan in old age, Xu M. et al., Nature Medicine (2018) 24(8): 1246–1256.