Загадка нестареющей медузы. Секреты природы и достижения науки, которые помогут приблизиться к вечной жизни

Influence on Longevity of Blueberry, Cinnamon, Green and Black Tea, Pomegranate, Sesame, Curcumin, Morin, Pycnogenol, Quercetin, and Taxifolin Fed Iso-Calorically to Long-Lived, F1 Hybrid Mice, Spindler S., Mote P., Flegal J., Teter B., Rejuvenation Research (2013) 16(2): 143–151.

Fisetin is a senotherapeutic that extends health and lifespan, Yousefzadeh M. et al., EBioMedicine (2018) 36: 18–28.

Mitochondria-targeted hydrogen sulfide attenuates endothelial senescence by selective induction of splicing factors HNRNPD and SRSF2, Latorre E., Torregrossa R., Wood M., Whiteman M., Harries L., Aging (2018) 10(7): 1666–1681.

Quercetin as an antiviral agent inhibits influenza a virus (IAV) Entry, Wu W., Li R., Li X., He J., Jiang S., Liu S., Yang J., Viruses (2015) 8(1).

Запасные детали биологии

The Nobel Prize in Physiology or Medicine 2016, NobelPrize.org, Nobel Media AB 2020.

Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors, Takahashi K., Yamanaka S., Cell (2006) 126(4): 663–676.

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming, Ocampo A. et al., Cell (2016) 167(7): 1719–1733.e12.

Transplantation of mesenchymal stem cells from young donors delays aging in mice, Shen J., Tsai Y., Dimarco N., Long M., Sun X., Tang L., Scientific Reports (2011) 1.

Photoaged Skin Therapy with Adipose-Derived Stem Cells, Charles-de-Sá L. et al., Plastic & Reconstructive Surgery (2020) 145(6): 1037e–1049e.

И сольются двое воедино

The effect of aging on human skeletal muscle mitochondrial and intramyocellular lipid ultrastructure, Crane J., Devries M., Safdar A., Hamadeh M., Tarnopolsky M., Journals of Gerontology — Series A Biological Sciences and Medical Sciences (2010) 65(2): 119–128.

Oxidative capacity and ageing in human muscle, Conley K., Jubrias S., Esselman P., Journal of Physiology (2000) 526(1): 203–210.

Update on mitochondria and muscle aging: All wrong roads lead to sarcopenia, Picca A. et al., Biological Chemistry.

Measuring In Vivo Mitophagy, Sun N. et al., Molecular Cell (2015) 60(4): 685–696.

Exercise is mitochondrial medicine for muscle, Oliveira A., Hood D., Sports Medicine and Health Science (2019) 1(1): 11–18.

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging, Van Remmen H. et al., Physiological Genomics (2004) 16(1): 29–37.

Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity Zhang Y. et al., Journals of Gerontology — Series A Biological Sciences and Medical Sciences (2009) 64(12): 1212–1220.

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans, Andreux P. A. et al., Nat Metab 1, 595–603 (2019).

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