Honea, R.A., et al., Cardiorespiratory fitness and preserved medial temporal lobe volume in Alzheimer disease.
Alzheimer Dis Assoc Disord, 2009. 23(3): p. 188–97.Pereira, A.C., et al., An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus.
Proc Natl Acad Sci U S A, 2007. 104(13): p. 5638–43.Burdette, J.H., et al., Using network science to evaluate exercise-associated brain changes in older adults.
Front Aging Neurosci, 2010. 2: p. 23–23.
Бег повышает уровень катепсина В:
Moon, H.Y., et al., Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function.
Cell Metab, 2016. 24(2): p. 332–40.
…физиологическое действие очень похоже на действие морфина, героина или никотина:
Fernandes, R.M., et al., The Effects of Moderate Physical Exercise on Adult Cognition: A Systematic Review.
Front Physiol, 2018. 9: p. 667.van den Berg, V., et al., Physical Activity in the School Setting: Cognitive Performance Is Not Affected by Three Different Types of Acute Exercise.
Front Psychol, 2016. 7: p. 723.Best, J.R., et al., Larger Lateral Prefrontal Cortex Volume Predicts Better Exercise Adherence Among Older Women: Evidence From Two Exercise Training Studies.
J Gerontol A Biol Sci Med Sci, 2017. 72(6): p. 804–810.Tsai, C.L., et al., Impact of acute aerobic exercise and cardiorespiratory fitness on visuospatial attention performance and serum BDNF levels.
Psychoneuroen docrinology, 2014. 41: p. 121–31.Olson, R.L., et al., Neurophysiological and behavioral correlates of cognitive control during low and moderate intensity exercise.
Neuroimage, 2016. 131: p. 171–80.Существует общее мнение о том, что физические упражнения в среднем возрасте предотвращают или отсрочивают деменцию в более позднем возрасте:
Alty J, Farrow M, Lawler K. Exercise and dementia prevention
. Pract Neurol, 2020 May;20(3): p. 234–240.
В части одного исследования участвовали мыши с измененными генами, которые способствовали развитию деменции:
Collins, A., et al., Exercise improves cognitive responses to psychological stress through enhancement of epigenetic mechanisms and gene expression in the dentate gyrus.
PLoS One, 2009. 4(1): e4330.Choi, S.H., et al., Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model.
Science, 2018. 361(6406): eaan8821.Maejima, H., et al., Exercise and low-level GABAA receptor inhibition modulate locomotor activity and the expression of BDNF accompanied by changes in epigenetic regulation in the hippocampus.
Neurosci Lett, 2018. 685: p. 18–23.Moon, H.Y., et al., Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function
Фоновое воспаление тесно связано с жировыми отложениями… Регулярные физические нагрузки снижают количество жира:
Ghilotti, F., et al., Obesity and risk of infections: results from men and women in the Swedish National March Cohort.
Int J Epidemiol, 2019. 48(6): p. 1783–1794.